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OPENSEQ.org
4HEA_H - 4HEA_K
UniProt: Q60019 - Q56226 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 460
Sequences: 2586
Seq/Len: 6.38
I_Prob: 0.20
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4heaHQ:KSContact Map
4he8CH:EKContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
138_L 25_I 1.16 0.20
238_S 25_I 1.13 0.18
202_A 36_N 1.12 0.18
217_T 68_V 0.97 0.11
148_S 43_V 0.96 0.11
96_A 42_L 0.94 0.10
254_T 55_V 0.93 0.10
164_L 83_E 0.89 0.09
84_L 43_V 0.88 0.08
238_S 41_S 0.87 0.08
137_F 40_L 0.87 0.08
68_F 40_L 0.86 0.08
284_A 14_G 0.85 0.07
88_I 15_V 0.85 0.07
122_I 33_L 0.85 0.07
67_I 75_I 0.84 0.07
56_L 38_A 0.83 0.07
295_A 61_I 0.82 0.07
64_I 54_Q 0.81 0.06
60_L 56_A 0.81 0.06
34_I 60_V 0.81 0.06
254_T 73_G 0.79 0.06
183_N 13_L 0.78 0.06
56_L 87_V 0.78 0.06
75_A 16_Y 0.78 0.06
146_K 69_A 0.77 0.06
300_L 26_L 0.77 0.05
210_S 69_A 0.77 0.05
171_L 25_I 0.77 0.05
194_W 25_I 0.77 0.05
126_F 72_L 0.77 0.05
87_L 49_Y 0.76 0.05
145_S 61_I 0.75 0.05
149_L 68_V 0.75 0.05
321_F 62_A 0.74 0.05
250_I 24_A 0.74 0.05
79_R 22_R 0.74 0.05
99_L 64_A 0.74 0.05
265_G 14_G 0.73 0.05
131_L 54_Q 0.73 0.05
267_W 16_Y 0.73 0.05
72_I 62_A 0.72 0.04
253_I 42_L 0.71 0.04
181_N 75_I 0.71 0.04
51_V 29_L 0.71 0.04
260_P 47_R 0.71 0.04
81_L 69_A 0.70 0.04
61_A 84_S 0.70 0.04
146_K 58_L 0.70 0.04
297_W 68_V 0.70 0.04
68_F 82_R 0.69 0.04
174_V 14_G 0.69 0.04
204_L 55_V 0.69 0.04
177_V 31_I 0.69 0.04
176_L 18_V 0.69 0.04
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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