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OPENSEQ.org

4HEA_H - 4HEA_J
UniProt: Q60019 - Q56225 Query Sequences:

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 541
Sequences: 1314
Seq/Len: 2.74
I_Prob: 1.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4heaHQ:JRContact Map
4he8CH:DJContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
120_L 53_F 3.02 1.00
81_L 27_H 1.61 0.93
78_D 27_H 1.51 0.89
305_L 52_G 1.44 0.86
322_L 20_V 1.32 0.79
302_Y 70_V 1.17 0.66
167_G 65_V 1.16 0.65
51_V 52_G 1.15 0.64
122_I 13_L 1.13 0.62
204_L 110_G 1.09 0.58
142_A 35_N 1.05 0.54
121_G 128_G 1.04 0.51
120_L 10_F 1.03 0.50
164_L 43_Y 1.01 0.48
92_F 57_I 0.99 0.46
131_L 37_L 0.98 0.44
195_L 18_L 0.97 0.44
302_Y 67_F 0.97 0.43
168_L 46_L 0.96 0.42
128_V 37_L 0.95 0.41
168_L 57_I 0.93 0.39
86_P 61_G 0.92 0.37
38_L 139_L 0.92 0.37
285_F 58_V 0.91 0.36
259_I 56_V 0.90 0.35
89_S 17_V 0.88 0.33
314_F 127_L 0.88 0.32
165_G 67_F 0.88 0.32
94_L 151_V 0.88 0.32
277_L 107_G 0.88 0.32
134_Y 70_V 0.87 0.32
224_A 153_A 0.87 0.31
203_F 31_A 0.87 0.31
169_A 13_L 0.86 0.30
316_L 13_L 0.85 0.30
139_S 29_A 0.85 0.30
97_F 36_F 0.85 0.29
68_F 57_I 0.85 0.29
314_F 37_L 0.85 0.29
83_V 144_F 0.85 0.29
302_Y 74_L 0.84 0.28
133_V 65_V 0.83 0.27
174_V 19_V 0.83 0.27
82_F 23_R 0.83 0.27
230_G 127_L 0.83 0.27
302_Y 25_A 0.82 0.27
305_L 152_V 0.81 0.25
135_G 23_R 0.81 0.25
180_L 124_P 0.81 0.25
164_L 150_T 0.81 0.25
81_L 30_L 0.81 0.25
63_A 42_V 0.81 0.25
24_L 126_A 0.80 0.24
87_L 56_V 0.80 0.24
196_F 40_A 0.79 0.23
322_L 101_A 0.79 0.23
184_D 125_Q 0.79 0.23
165_G 150_T 0.79 0.23
79_R 41_G 0.79 0.23
132_A 138_V 0.79 0.23
242_A 156_L 0.79 0.23
118_L 49_R 0.78 0.22
165_G 35_N 0.78 0.22
78_D 56_V 0.78 0.22
81_L 127_L 0.78 0.22
68_F 63_I 0.78 0.22
71_D 38_V 0.78 0.22
157_A 29_A 0.78 0.21
139_S 63_I 0.77 0.21
17_A 45_A 0.77 0.21
300_L 142_V 0.77 0.21
50_R 64_V 0.77 0.21
169_A 132_Y 0.77 0.21
134_Y 74_L 0.77 0.21
260_P 17_V 0.77 0.21
134_Y 132_Y 0.77 0.21
309_G 64_V 0.77 0.21
240_K 51_L 0.77 0.21
226_Q 60_A 0.76 0.20
176_L 8_A 0.76 0.20
237_S 16_G 0.76 0.20
300_L 73_L 0.76 0.20
85_A 14_L 0.75 0.20
178_G 40_A 0.75 0.20
294_R 61_G 0.75 0.20
232_Y 100_V 0.75 0.19
159_L 64_V 0.75 0.19
99_L 30_L 0.75 0.19
204_L 12_L 0.75 0.19
281_L 141_A 0.75 0.19
228_L 63_I 0.75 0.19
126_F 29_A 0.75 0.19
228_L 16_G 0.75 0.19
289_F 134_D 0.75 0.19
184_D 10_F 0.74 0.19
120_L 9_L 0.74 0.19
233_H 38_V 0.74 0.19
94_L 157_V 0.74 0.18
102_F 159_P 0.74 0.18
156_S 141_A 0.74 0.18
84_L 144_F 0.74 0.18
239_I 41_G 0.74 0.18
230_G 45_A 0.74 0.18
258_L 26_I 0.73 0.18
20_V 127_L 0.73 0.18
173_P 135_W 0.73 0.18
60_L 99_G 0.73 0.17
306_L 72_M 0.72 0.17
134_Y 25_A 0.72 0.17
179_S 36_F 0.72 0.17
94_L 11_L 0.72 0.17
313_L 103_I 0.72 0.17
116_I 37_L 0.72 0.17
247_A 99_G 0.72 0.17
92_F 140_L 0.72 0.17
77_A 39_L 0.72 0.16
197_L 26_I 0.72 0.16
126_F 25_A 0.72 0.16
238_S 44_V 0.71 0.16
291_I 68_L 0.71 0.16
262_L 66_L 0.71 0.16
289_F 58_V 0.71 0.16
164_L 27_H 0.71 0.16
222_P 143_G 0.71 0.16
181_N 20_V 0.71 0.16
85_A 5_E 0.71 0.16
309_G 72_M 0.70 0.16
158_S 152_V 0.70 0.15
226_Q 25_A 0.70 0.15
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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