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OPENSEQ.org
4HEA_L - 4HEA_N
UniProt: Q56227 - Q56229 Query Sequences:
Length: 1033
Sequences: 3703
Seq/Len: 3.65
I_Prob: 0.86
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4he8FL:IN:GM:GM:FL:INContact Map
4heaLT:NV:MU:MU:LT:NVContact Map
3rkoBL:DN:CM:DN:CM:BLContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
590_A 139_L 1.57 0.86
103_R 260_Y 1.52 0.83
582_Q 247_A 1.49 0.82
571_A 249_L 1.38 0.74
578_L 247_A 1.27 0.65
120_L 147_F 1.17 0.56
571_A 246_L 1.14 0.53
176_L 138_L 1.07 0.46
67_L 237_V 1.03 0.41
476_A 238_A 1.03 0.41
207_L 376_L 1.00 0.37
451_L 223_L 0.98 0.36
110_L 237_V 0.98 0.36
473_L 360_V 0.97 0.34
110_L 379_G 0.96 0.34
147_K 235_L 0.95 0.32
582_Q 260_Y 0.93 0.30
185_I 282_G 0.92 0.29
208_L 192_F 0.90 0.28
358_H 260_Y 0.90 0.28
566_G 327_L 0.89 0.26
90_Y 267_G 0.86 0.24
87_I 339_L 0.86 0.23
155_A 268_Y 0.85 0.23
589_Y 194_F 0.84 0.22
190_E 239_L 0.84 0.22
332_L 333_L 0.84 0.22
260_Y 257_L 0.83 0.22
533_Y 299_L 0.83 0.21
354_G 348_A 0.83 0.21
185_I 97_L 0.83 0.21
31_V 373_Y 0.82 0.20
185_I 132_A 0.82 0.20
212_G 137_F 0.81 0.20
256_S 192_F 0.81 0.19
583_T 198_D 0.81 0.19
389_L 340_A 0.80 0.19
295_V 299_L 0.80 0.19
584_G 198_D 0.80 0.18
172_G 312_L 0.79 0.18
445_P 177_G 0.79 0.18
116_L 302_I 0.79 0.18
445_P 105_L 0.79 0.18
120_L 238_A 0.79 0.18
257_S 327_L 0.79 0.18
275_L 255_K 0.79 0.18
124_Y 296_F 0.78 0.17
586_L 138_L 0.78 0.17
75_F 245_N 0.78 0.17
448_L 286_L 0.77 0.17
533_Y 367_T 0.77 0.17
293_K 265_H 0.77 0.16
338_S 141_A 0.77 0.16
320_F 374_Y 0.77 0.16
567_L 239_L 0.76 0.16
502_L 235_L 0.76 0.16
185_I 192_F 0.76 0.16
154_S 211_M 0.76 0.16
176_L 192_F 0.76 0.16
259_L 132_A 0.76 0.16
372_A 202_G 0.76 0.16
307_F 260_Y 0.76 0.15
365_H 266_A 0.75 0.15
75_F 133_A 0.75 0.15
238_A 267_G 0.75 0.15
451_L 271_L 0.75 0.15
89_V 182_G 0.75 0.15
74_G 226_V 0.75 0.15
140_L 148_L 0.74 0.15
507_A 233_L 0.74 0.15
180_Y 367_T 0.74 0.15
366_A 373_Y 0.74 0.15
504_G 258_L 0.74 0.15
318_A 188_A 0.74 0.15
566_G 97_L 0.74 0.14
308_L 94_G 0.74 0.14
566_G 194_F 0.74 0.14
275_L 361_L 0.74 0.14
260_Y 157_A 0.73 0.14
367_L 293_G 0.73 0.14
211_L 232_A 0.73 0.14
392_T 133_A 0.73 0.14
257_S 364_A 0.73 0.14
521_Y 97_L 0.73 0.14
188_L 324_L 0.73 0.14
130_G 219_A 0.73 0.14
90_Y 252_K 0.73 0.14
549_L 323_G 0.72 0.13
160_I 272_A 0.72 0.13
91_A 148_L 0.72 0.13
420_W 185_F 0.72 0.13
507_A 146_F 0.72 0.13
113_A 360_V 0.72 0.13
331_L 374_Y 0.72 0.13
273_V 189_L 0.72 0.13
492_G 273_L 0.72 0.13
550_A 257_L 0.72 0.13
359_L 373_Y 0.72 0.13
91_A 379_G 0.72 0.13
453_S 94_G 0.72 0.13
359_L 327_L 0.71 0.13
457_G 344_G 0.71 0.13
424_V 224_L 0.71 0.13
418_M 327_L 0.71 0.12
420_W 289_V 0.71 0.12
330_A 132_A 0.71 0.12
172_G 321_L 0.71 0.12
424_V 126_R 0.71 0.12
424_V 271_L 0.71 0.12
575_G 220_F 0.70 0.12
158_A 198_D 0.70 0.12
169_F 370_V 0.70 0.12
361_Q 111_L 0.70 0.12
338_S 107_M 0.70 0.12
371_L 285_L 0.70 0.12
592_L 194_F 0.70 0.12
308_L 141_A 0.70 0.12
313_G 132_A 0.70 0.12
368_I 363_L 0.70 0.12
550_A 360_V 0.70 0.12
572_R 367_T 0.70 0.12
357_K 364_A 0.70 0.12
566_G 139_L 0.70 0.12
566_G 244_G 0.70 0.12
438_A 132_A 0.70 0.12
265_D 290_L 0.69 0.12
307_F 141_A 0.69 0.12
392_T 310_E 0.69 0.12
455_L 192_F 0.69 0.12
294_I 248_A 0.69 0.12
424_V 284_Y 0.69 0.12
414_A 147_F 0.69 0.12
185_I 241_V 0.69 0.11
212_G 197_P 0.69 0.11
581_L 192_F 0.69 0.11
172_G 295_A 0.69 0.11
205_A 324_L 0.69 0.11
102_S 96_H 0.69 0.11
250_V 182_G 0.69 0.11
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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