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OPENSEQ.org
4HEA_L - 4HEA_M
UniProt: Q56227 - Q56228 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 1075
Sequences: 3827
Seq/Len: 3.64
I_Prob: 1.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4heaLT:MU:LT:MU:NV:NVContact Map
4he8FL:GM:FL:GM:IN:INContact Map
3rkoBL:CM:BL:CM:DN:DNContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
160_I 404_A 2.58 1.00
159_F 407_L 2.37 0.99
139_F 411_Q 2.00 0.98
171_L 396_F 1.85 0.97
170_M 399_V 1.56 0.93
174_A 381_L 1.55 0.93
167_L 399_V 1.45 0.89
167_L 400_I 1.37 0.86
143_G 411_Q 1.34 0.84
565_F 143_R 1.33 0.84
167_L 396_F 1.27 0.80
145_W 148_F 1.14 0.69
562_S 147_T 1.09 0.64
171_L 392_A 1.07 0.61
330_A 329_A 0.98 0.51
86_L 208_F 0.95 0.47
409_V 224_S 0.91 0.43
167_L 269_L 0.90 0.41
355_L 174_T 0.89 0.40
372_A 407_L 0.89 0.40
375_G 319_G 0.88 0.39
90_Y 344_Y 0.88 0.39
223_M 293_M 0.87 0.37
372_A 212_A 0.85 0.35
562_S 143_R 0.84 0.34
87_I 231_G 0.84 0.34
109_N 296_A 0.83 0.33
130_G 225_G 0.82 0.32
133_G 225_G 0.82 0.32
142_I 84_L 0.82 0.31
174_A 382_L 0.82 0.31
265_D 311_G 0.81 0.30
380_S 81_T 0.81 0.30
562_S 212_A 0.81 0.30
95_M 291_S 0.81 0.30
314_A 401_A 0.81 0.30
312_V 300_V 0.80 0.29
334_L 407_L 0.80 0.29
60_L 375_P 0.80 0.29
310_A 207_L 0.80 0.29
446_N 338_T 0.79 0.28
550_A 277_A 0.79 0.28
159_F 368_L 0.79 0.28
532_F 273_W 0.79 0.28
136_L 368_L 0.79 0.27
71_N 298_L 0.78 0.27
161_V 284_L 0.78 0.27
208_L 393_A 0.78 0.27
312_V 430_W 0.77 0.26
332_L 341_I 0.77 0.26
424_V 321_Y 0.77 0.26
442_M 294_G 0.77 0.25
515_K 312_L 0.76 0.25
282_A 285_L 0.76 0.25
90_Y 153_L 0.76 0.25
169_F 194_F 0.76 0.25
231_A 119_Y 0.76 0.25
350_R 220_E 0.76 0.25
208_L 100_L 0.76 0.24
335_A 87_L 0.76 0.24
332_L 376_G 0.76 0.24
546_L 273_W 0.75 0.24
455_L 65_F 0.75 0.24
454_V 299_G 0.75 0.24
125_P 378_F 0.75 0.24
459_L 312_L 0.75 0.24
172_G 381_L 0.75 0.23
123_S 243_R 0.75 0.23
398_G 431_G 0.74 0.23
227_P 156_S 0.74 0.23
381_G 126_L 0.74 0.22
170_M 381_L 0.74 0.22
128_F 374_F 0.74 0.22
418_M 177_L 0.74 0.22
340_I 152_T 0.73 0.22
171_L 297_A 0.73 0.22
67_L 281_F 0.73 0.22
269_A 244_F 0.73 0.22
146_Y 349_Q 0.73 0.22
212_G 374_F 0.73 0.22
412_L 338_T 0.73 0.21
391_A 154_V 0.73 0.21
453_S 200_A 0.72 0.21
91_A 285_L 0.72 0.21
418_M 321_Y 0.72 0.21
446_N 347_L 0.72 0.20
550_A 379_L 0.71 0.20
95_M 137_G 0.71 0.20
349_V 338_T 0.71 0.20
140_L 314_L 0.71 0.20
412_L 107_L 0.71 0.19
40_S 146_Y 0.70 0.19
79_I 434_L 0.70 0.19
310_A 102_M 0.70 0.19
164_I 400_I 0.70 0.19
238_A 231_G 0.70 0.19
406_A 402_S 0.70 0.19
502_L 355_A 0.70 0.19
331_L 109_L 0.70 0.19
373_L 220_E 0.70 0.19
293_K 219_Q 0.70 0.19
451_L 78_I 0.70 0.18
327_F 131_L 0.69 0.18
99_P 364_A 0.69 0.18
415_M 210_L 0.69 0.18
119_V 325_L 0.69 0.18
110_L 257_Q 0.69 0.18
257_S 312_L 0.69 0.18
343_L 356_A 0.69 0.18
442_M 242_F 0.69 0.18
372_A 399_V 0.69 0.18
499_A 112_A 0.69 0.18
117_T 161_A 0.69 0.18
451_L 372_S 0.69 0.18
281_G 135_L 0.69 0.18
216_K 204_K 0.69 0.18
139_F 335_R 0.69 0.18
566_G 403_A 0.68 0.17
368_I 360_I 0.68 0.17
290_D 292_H 0.68 0.17
591_L 65_F 0.68 0.17
156_R 411_Q 0.68 0.17
368_I 121_F 0.68 0.17
63_I 262_F 0.68 0.17
419_R 151_F 0.68 0.17
334_L 399_V 0.68 0.17
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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