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OPENSEQ.org
4HEA_K - 4HEA_N
UniProt: Q56226 - Q56229 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 522
Sequences: 3467
Seq/Len: 6.71
I_Prob: 1.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3rkoDN:CM:BL:GKContact Map
4he8IN:FL:GM:EKContact Map
4heaNV:LT:MU:KSContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
41_S 152_A 2.60 1.00
63_V 109_V 2.29 0.99
71_G 137_F 2.00 0.99
45_F 156_G 1.60 0.95
15_V 142_L 1.43 0.91
18_V 142_L 1.43 0.91
56_A 105_L 1.43 0.91
42_L 220_F 1.41 0.90
38_A 148_L 1.35 0.88
18_V 138_L 1.30 0.85
22_R 266_A 1.22 0.81
14_G 187_A 1.18 0.77
16_Y 194_F 1.18 0.77
11_F 149_Y 1.12 0.73
93_L 256_R 1.07 0.68
13_L 343_W 1.03 0.63
24_A 264_A 1.02 0.62
24_A 134_L 1.01 0.61
21_R 94_G 1.01 0.61
9_L 370_V 1.00 0.59
81_H 130_L 0.99 0.58
20_T 298_V 0.97 0.56
73_G 220_F 0.95 0.54
73_G 373_Y 0.94 0.53
58_L 204_P 0.94 0.53
53_G 284_Y 0.93 0.51
60_V 196_T 0.93 0.51
22_R 272_A 0.91 0.49
93_L 202_G 0.89 0.46
56_A 258_L 0.89 0.46
27_V 138_L 0.88 0.44
70_V 192_F 0.87 0.44
59_M 97_L 0.87 0.44
10_L 329_A 0.86 0.43
46_A 150_G 0.86 0.42
43_V 327_L 0.85 0.41
74_L 134_L 0.84 0.40
58_L 210_F 0.84 0.40
69_A 132_A 0.84 0.40
90_L 103_H 0.84 0.39
20_T 258_L 0.84 0.39
25_I 203_S 0.83 0.39
61_I 146_F 0.83 0.39
78_I 204_P 0.83 0.39
19_L 366_V 0.83 0.38
70_V 119_Y 0.83 0.38
31_I 141_A 0.81 0.36
18_V 281_L 0.81 0.35
65_A 330_M 0.81 0.35
73_G 260_Y 0.80 0.35
70_V 116_L 0.79 0.34
64_A 265_H 0.79 0.33
47_R 325_A 0.79 0.33
58_L 290_L 0.79 0.33
70_V 133_A 0.78 0.32
22_R 222_A 0.77 0.32
84_S 260_Y 0.77 0.32
79_F 189_L 0.77 0.32
72_L 112_E 0.77 0.31
50_G 179_L 0.77 0.31
88_D 97_L 0.76 0.30
55_V 319_D 0.76 0.30
34_M 145_A 0.76 0.30
25_I 208_V 0.76 0.30
64_A 149_Y 0.76 0.29
65_A 251_Q 0.76 0.29
33_L 254_A 0.75 0.29
29_L 247_A 0.75 0.29
29_L 291_A 0.75 0.28
18_V 329_A 0.75 0.28
46_A 260_Y 0.75 0.28
57_A 292_T 0.74 0.28
37_A 198_D 0.74 0.27
38_A 109_V 0.74 0.27
16_Y 179_L 0.73 0.27
93_L 131_E 0.73 0.27
44_G 236_L 0.73 0.27
18_V 353_A 0.73 0.26
60_V 148_L 0.73 0.26
84_S 305_D 0.73 0.26
13_L 307_V 0.72 0.26
39_N 241_V 0.72 0.26
62_A 376_L 0.72 0.26
49_Y 254_A 0.72 0.26
77_A 267_G 0.72 0.25
16_Y 146_F 0.71 0.25
79_F 185_F 0.71 0.24
32_E 288_Y 0.71 0.24
32_E 216_K 0.71 0.24
42_L 105_L 0.70 0.24
59_M 361_L 0.70 0.24
16_Y 226_V 0.70 0.24
50_G 363_L 0.70 0.24
50_G 155_Y 0.70 0.23
13_L 285_L 0.69 0.23
30_S 101_T 0.69 0.23
55_V 228_A 0.69 0.22
8_A 149_Y 0.69 0.22
15_V 326_F 0.69 0.22
49_Y 93_L 0.69 0.22
45_F 203_S 0.69 0.22
14_G 295_A 0.68 0.21
19_L 283_F 0.68 0.21
33_L 184_G 0.68 0.21
51_L 164_G 0.68 0.21
29_L 123_T 0.68 0.21
12_A 181_V 0.68 0.21
63_V 336_L 0.68 0.21
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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