May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
4HEA_J - 4HEA_K
UniProt: Q56225 - Q56226 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 271
Sequences: 1376
Seq/Len: 5.40
I_Prob: 1.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3rkoFJ:GKContact Map
4heaJR:KSContact Map
4he8DJ:EKContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
13_L 9_L 3.31 1.00
17_V 13_L 2.86 1.00
16_G 10_L 2.10 0.99
130_L 51_L 1.87 0.98
6_G 2_S 1.74 0.97
19_V 29_L 1.71 0.97
39_L 40_L 1.65 0.96
142_V 62_A 1.52 0.93
20_V 17_G 1.43 0.91
42_V 6_T 1.35 0.88
157_V 76_V 1.34 0.87
29_A 29_L 1.32 0.86
145_L 70_V 1.30 0.85
73_L 28_F 1.27 0.83
44_V 93_L 1.23 0.81
25_A 68_V 1.18 0.77
130_L 52_D 1.16 0.75
55_Q 36_N 1.15 0.74
35_N 33_L 1.14 0.73
142_V 61_I 1.13 0.72
72_M 54_Q 1.10 0.69
9_L 60_V 1.09 0.69
47_D 91_S 1.07 0.67
138_V 59_M 1.06 0.66
16_G 13_L 1.05 0.65
58_V 87_V 1.02 0.62
28_A 7_S 1.02 0.61
62_A 82_R 1.01 0.60
48_A 43_V 1.01 0.60
43_Y 36_N 1.01 0.60
11_L 37_A 0.97 0.56
128_G 68_V 0.97 0.55
127_L 55_V 0.97 0.55
152_V 94_R 0.96 0.55
20_V 21_R 0.96 0.54
54_I 94_R 0.95 0.53
20_V 70_V 0.94 0.52
4_L 93_L 0.94 0.52
47_D 47_R 0.92 0.49
43_Y 58_L 0.91 0.48
39_L 6_T 0.91 0.48
144_F 7_S 0.91 0.48
46_L 44_G 0.91 0.47
29_A 45_F 0.89 0.46
64_V 58_L 0.89 0.46
71_I 41_S 0.89 0.45
131_L 10_L 0.88 0.44
48_A 54_Q 0.88 0.44
59_Y 72_L 0.88 0.44
148_A 79_F 0.88 0.43
93_A 9_L 0.87 0.43
20_V 16_Y 0.87 0.42
64_V 29_L 0.86 0.42
40_A 44_G 0.86 0.41
151_V 20_T 0.86 0.41
40_A 16_Y 0.85 0.41
28_A 29_L 0.85 0.41
77_A 75_I 0.83 0.38
106_A 94_R 0.82 0.37
100_V 15_V 0.82 0.37
46_L 47_R 0.82 0.36
142_V 48_A 0.82 0.36
98_L 93_L 0.82 0.36
156_L 60_V 0.81 0.35
124_P 54_Q 0.81 0.35
49_R 60_V 0.80 0.34
48_A 44_G 0.79 0.32
74_L 85_T 0.79 0.32
137_F 77_A 0.78 0.32
137_F 90_L 0.78 0.32
71_I 25_I 0.77 0.31
11_L 81_H 0.77 0.30
129_P 24_A 0.77 0.30
60_A 28_F 0.76 0.30
124_P 63_V 0.76 0.29
101_A 8_A 0.76 0.29
9_L 6_T 0.76 0.29
7_L 11_F 0.75 0.28
153_A 23_T 0.75 0.28
32_L 31_I 0.75 0.28
105_A 5_L 0.75 0.28
32_L 15_V 0.75 0.28
63_I 55_V 0.75 0.28
41_G 87_V 0.75 0.28
155_A 28_F 0.75 0.28
129_P 7_S 0.75 0.28
67_F 31_I 0.74 0.27
136_L 57_A 0.74 0.27
45_A 35_L 0.74 0.27
156_L 77_A 0.74 0.27
16_G 86_A 0.74 0.27
153_A 28_F 0.74 0.27
43_Y 40_L 0.74 0.27
151_V 75_I 0.74 0.27
40_A 7_S 0.74 0.26
7_L 27_V 0.74 0.26
51_L 70_V 0.73 0.26
12_L 40_L 0.73 0.26
53_F 36_N 0.73 0.26
47_D 14_G 0.73 0.26
74_L 73_G 0.73 0.26
55_Q 61_I 0.73 0.26
43_Y 14_G 0.73 0.26
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
Page generated in 0.223 seconds.