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OPENSEQ.org
4HEA_9 - 4HEA_H
UniProt: Q56224 - Q60019 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 547
Sequences: 1541
Seq/Len: 3.31
I_Prob: 0.99
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4heaHQ:9O:9OContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
6_L 297_W 2.17 0.99
28_D 50_R 2.01 0.98
25_P 46_M 1.45 0.88
16_Y 44_V 1.39 0.85
21_P 41_R 1.38 0.84
13_T 296_T 1.34 0.82
13_T 292_W 1.14 0.66
17_L 41_R 0.95 0.44
100_F 85_A 0.88 0.36
21_P 46_M 0.87 0.34
17_L 38_L 0.78 0.24
20_K 59_P 0.78 0.24
60_A 245_Q 0.77 0.23
116_G 82_F 0.77 0.23
99_I 142_A 0.76 0.22
60_A 202_A 0.74 0.20
10_L 297_W 0.73 0.20
31_V 166_L 0.73 0.20
32_A 170_L 0.72 0.19
96_L 242_A 0.72 0.19
71_E 25_L 0.72 0.18
97_R 226_Q 0.71 0.18
109_P 48_P 0.71 0.18
10_L 289_F 0.70 0.17
51_E 288_F 0.69 0.16
73_A 243_L 0.69 0.16
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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