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OPENSEQ.org

4HEA_3 - 4HEA_H
UniProt: Q56223 - Q60019 Query Sequences:

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 1148
Sequences: 1653
Seq/Len: 1.61
I_Prob: 0.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea3D:HQ:9OContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
413_L 26_T 0.92 0.00
577_L 88_I 0.83 0.00
408_I 67_I 0.80 0.00
481_L 57_L 0.77 0.00
326_F 152_S 0.76 0.00
408_I 57_L 0.76 0.00
621_V 124_Y 0.75 0.00
328_A 260_P 0.74 0.00
497_W 180_L 0.74 0.00
472_E 95_L 0.73 0.00
576_A 281_L 0.73 0.00
331_E 64_I 0.73 0.00
255_T 290_F 0.73 0.00
578_K 88_I 0.73 0.00
320_A 34_I 0.72 0.00
365_K 117_N 0.71 0.00
505_L 136_I 0.68 0.00
342_G 102_F 0.68 0.00
321_T 207_L 0.68 0.00
594_A 281_L 0.67 0.00
664_L 178_G 0.67 0.00
386_S 179_S 0.67 0.00
333_L 284_A 0.67 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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