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OPENSEQ.org
4HEA_3 - 4HEA_K
UniProt: Q56223 - Q56226 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 878
Sequences: 1626
Seq/Len: 2.04
I_Prob: 0.03
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea3D:KS:9O:JRContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
320_A 79_F 1.22 0.03
310_L 79_F 1.11 0.02
648_L 38_A 0.88 0.01
640_V 43_V 0.86 0.01
357_A 22_R 0.83 0.01
311_V 24_A 0.82 0.01
656_L 27_V 0.79 0.01
326_F 69_A 0.78 0.01
643_L 38_A 0.78 0.01
501_K 22_R 0.77 0.01
602_L 56_A 0.76 0.01
358_S 68_V 0.74 0.01
331_E 84_S 0.73 0.01
271_S 29_L 0.73 0.01
654_F 88_D 0.73 0.01
357_A 15_V 0.72 0.01
719_H 9_L 0.72 0.01
321_T 7_S 0.72 0.01
583_V 15_V 0.71 0.01
633_E 44_G 0.71 0.01
378_P 7_S 0.70 0.01
281_E 40_L 0.70 0.01
584_V 57_A 0.70 0.01
451_F 46_A 0.69 0.01
625_S 77_A 0.69 0.01
334_K 19_L 0.68 0.01
499_K 27_V 0.68 0.01
708_A 21_R 0.68 0.01
396_A 25_I 0.67 0.01
361_A 55_V 0.67 0.01
323_E 20_T 0.67 0.01
583_V 49_Y 0.66 0.01
526_E 60_V 0.66 0.01
456_A 7_S 0.65 0.01
386_S 55_V 0.65 0.00
734_V 20_T 0.64 0.00
394_D 66_A 0.64 0.00
513_Q 24_A 0.64 0.00
361_A 66_A 0.64 0.00
261_V 25_I 0.64 0.00
584_V 51_L 0.64 0.00
618_E 68_V 0.64 0.00
329_L 84_S 0.63 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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