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OPENSEQ.org

4HEA_3 - 4HEA_5
UniProt: Q56223 - Q56219 Query Sequences:

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 990
Sequences: 1688
Seq/Len: 1.97
I_Prob: 0.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3ias3UCL:5NEW:4DVM:9YGPContact Map
3i9v3C:5E:4D:9GContact Map
2fug3CLU:5NEW:4VMD:9YPGContact Map
3m9s3C:5E:4D:9GContact Map
3iam3C:5E:4D:9GContact Map
4hea3D:5F:4E:9OContact Map
2ybb3:5:4:8Contact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
357_A 107_L 0.96 0.00
387_L 104_V 0.90 0.00
583_V 88_F 0.86 0.00
311_V 107_L 0.83 0.00
343_L 103_T 0.81 0.00
654_F 68_F 0.78 0.00
492_K 119_Y 0.77 0.00
612_G 122_F 0.76 0.00
336_A 27_V 0.76 0.00
326_F 90_V 0.76 0.00
278_R 122_F 0.75 0.00
484_K 29_L 0.74 0.00
568_Y 107_L 0.74 0.00
399_L 104_V 0.74 0.00
324_E 105_T 0.74 0.00
392_Q 32_E 0.72 0.00
341_V 105_T 0.72 0.00
408_I 110_S 0.70 0.00
408_I 146_L 0.69 0.00
314_E 128_G 0.68 0.00
395_F 104_V 0.68 0.00
496_A 34_F 0.67 0.00
498_E 88_F 0.67 0.00
506_I 92_V 0.67 0.00
456_A 31_R 0.67 0.00
584_V 142_E 0.66 0.00
634_A 90_V 0.66 0.00
475_E 121_L 0.66 0.00
592_P 72_Y 0.65 0.00
518_A 127_E 0.65 0.00
353_E 121_L 0.65 0.00
584_V 35_K 0.65 0.00
329_L 90_V 0.65 0.00
659_E 103_T 0.64 0.00
380_S 54_G 0.64 0.00
365_K 110_S 0.64 0.00
341_V 70_V 0.64 0.00
262_G 54_G 0.64 0.00
668_K 29_L 0.64 0.00
326_F 41_Y 0.63 0.00
480_L 107_L 0.63 0.00
644_L 27_V 0.62 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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