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OPENSEQ.org
4HEA_3 - 4HEA_A
UniProt: Q56223 - Q56217 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 902
Sequences: 1257
Seq/Len: 1.53
I_Prob: 0.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea3D:AP:9OContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
576_A 56_R 1.03 0.00
449_A 19_F 1.03 0.00
603_P 111_W 1.02 0.00
319_E 16_V 1.01 0.00
472_E 61_F 1.00 0.00
331_E 18_L 1.00 0.00
479_A 43_P 0.98 0.00
357_A 24_A 0.98 0.00
480_L 37_G 0.92 0.00
502_N 108_L 0.92 0.00
564_L 27_V 0.92 0.00
328_A 19_F 0.91 0.00
265_I 84_S 0.91 0.00
290_I 29_A 0.91 0.00
254_T 19_F 0.89 0.00
396_A 87_G 0.87 0.00
628_P 77_F 0.86 0.00
495_E 18_L 0.86 0.00
396_A 35_K 0.85 0.00
367_P 96_V 0.85 0.00
664_L 61_F 0.85 0.00
644_L 44_Y 0.85 0.00
349_A 92_G 0.84 0.00
365_K 65_A 0.84 0.00
353_E 85_A 0.84 0.00
413_L 50_P 0.83 0.00
272_G 108_L 0.81 0.00
341_V 12_I 0.80 0.00
335_E 98_A 0.80 0.00
361_A 17_A 0.80 0.00
272_G 53_E 0.80 0.00
627_A 64_V 0.80 0.00
531_K 13_Y 0.79 0.00
408_I 10_T 0.79 0.00
361_A 117_R 0.79 0.00
468_H 30_L 0.78 0.00
549_V 44_Y 0.77 0.00
505_L 22_V 0.77 0.00
321_T 26_L 0.77 0.00
469_R 19_F 0.77 0.00
392_Q 59_V 0.77 0.00
8_D 31_L 0.76 0.00
308_T 42_M 0.76 0.00
365_K 115_V 0.75 0.00
345_L 75_V 0.75 0.00
511_V 117_R 0.75 0.00
563_A 105_V 0.75 0.00
524_L 108_L 0.75 0.00
400_G 107_F 0.74 0.00
451_F 16_V 0.74 0.00
333_L 54_V 0.74 0.00
506_I 84_S 0.73 0.00
404_E 62_Y 0.73 0.00
347_H 93_F 0.73 0.00
532_V 13_Y 0.73 0.00
476_I 101_L 0.73 0.00
719_H 12_I 0.73 0.00
719_H 100_T 0.72 0.00
386_S 87_G 0.72 0.00
414_S 69_I 0.72 0.00
301_A 67_L 0.72 0.00
666_A 98_A 0.72 0.00
451_F 114_G 0.71 0.00
311_V 98_A 0.71 0.00
396_A 31_L 0.71 0.00
602_L 13_Y 0.70 0.00
402_P 117_R 0.70 0.00
397_L 50_P 0.70 0.00
360_L 112_W 0.70 0.00
412_R 73_V 0.70 0.00
496_A 12_I 0.69 0.00
602_L 64_V 0.69 0.00
399_L 97_L 0.69 0.00
635_E 119_H 0.69 0.00
323_E 34_K 0.69 0.00
601_V 41_L 0.69 0.00
314_E 108_L 0.69 0.00
603_P 114_G 0.68 0.00
655_R 108_L 0.68 0.00
547_M 60_H 0.68 0.00
521_A 102_L 0.68 0.00
398_V 70_L 0.68 0.00
354_G 46_S 0.68 0.00
409_L 44_Y 0.68 0.00
310_L 22_V 0.68 0.00
613_H 30_L 0.68 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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