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OPENSEQ.org

4HEA_1 - 4HEA_K
UniProt: Q56222 - Q56226 Query Sequences:

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 533
Sequences: 999
Seq/Len: 1.97
I_Prob: 0.01
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea1B:KSContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
121_A 79_F 1.17 0.01
171_L 58_L 1.03 0.01
186_T 28_F 0.80 0.00
80_P 42_L 0.80 0.00
143_D 37_A 0.79 0.00
273_R 54_Q 0.78 0.00
57_V 89_D 0.77 0.00
373_K 63_V 0.77 0.00
325_T 54_Q 0.75 0.00
238_F 74_L 0.74 0.00
81_K 30_S 0.73 0.00
276_I 70_V 0.73 0.00
131_Y 62_A 0.72 0.00
233_R 30_S 0.71 0.00
330_L 75_I 0.70 0.00
290_I 33_L 0.70 0.00
232_E 9_L 0.69 0.00
170_D 75_I 0.68 0.00
114_L 24_A 0.67 0.00
308_D 10_L 0.67 0.00
201_L 57_A 0.67 0.00
33_L 9_L 0.67 0.00
315_H 30_S 0.67 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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