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OPENSEQ.org
4HEA_1 - 4HEA_J
UniProt: Q56222 - Q56225 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 614
Sequences: 876
Seq/Len: 1.52
I_Prob: 0.01
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea1B:JRContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
107_L 56_V 1.26 0.01
422_L 56_V 1.07 0.01
370_L 94_A 1.01 0.01
252_Y 28_A 0.96 0.00
161_N 108_L 0.93 0.00
217_T 153_A 0.89 0.00
238_F 129_P 0.89 0.00
115_I 13_L 0.88 0.00
130_G 124_P 0.87 0.00
223_T 143_G 0.86 0.00
275_L 70_V 0.83 0.00
260_R 10_F 0.82 0.00
142_A 157_V 0.82 0.00
276_I 152_V 0.81 0.00
370_L 141_A 0.81 0.00
268_M 131_L 0.81 0.00
335_V 52_G 0.81 0.00
231_M 49_R 0.80 0.00
121_A 32_L 0.80 0.00
53_V 3_L 0.80 0.00
330_L 25_A 0.80 0.00
328_V 105_A 0.78 0.00
107_L 76_A 0.78 0.00
168_S 9_L 0.77 0.00
155_R 71_I 0.77 0.00
327_G 16_G 0.76 0.00
389_A 71_I 0.76 0.00
202_K 51_L 0.76 0.00
59_R 128_G 0.76 0.00
238_F 47_D 0.76 0.00
154_A 22_L 0.75 0.00
36_G 44_V 0.74 0.00
378_Q 54_I 0.74 0.00
52_E 160_G 0.74 0.00
389_A 156_L 0.74 0.00
276_I 57_I 0.73 0.00
302_F 102_G 0.73 0.00
146_E 57_I 0.72 0.00
158_L 127_L 0.72 0.00
170_D 105_A 0.72 0.00
42_K 20_V 0.72 0.00
132_I 14_L 0.72 0.00
71_P 156_L 0.72 0.00
300_L 79_G 0.71 0.00
227_V 11_L 0.71 0.00
115_I 54_I 0.71 0.00
274_E 80_E 0.70 0.00
289_A 37_L 0.70 0.00
231_M 71_I 0.70 0.00
227_V 20_V 0.70 0.00
271_T 105_A 0.69 0.00
128_T 143_G 0.69 0.00
276_I 71_I 0.69 0.00
378_Q 17_V 0.69 0.00
367_M 33_I 0.69 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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