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OPENSEQ.org
4HEA_1 - 4HEA_2
UniProt: Q56222 - Q56221 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 619
Sequences: 1694
Seq/Len: 2.92
I_Prob: 0.48
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3ias1SJA:2TKBContact Map
3i9v1A:2BContact Map
3m9s1A:2BContact Map
2fug1SAJ:2TKBContact Map
3iam1A:2BContact Map
4hea1B:2CContact Map
2ybb1:2Contact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
138_Y 126_G 1.39 0.48
101_F 129_H 0.94 0.14
212_W 25_A 0.86 0.10
339_D 94_E 0.85 0.10
415_R 95_E 0.79 0.08
284_L 91_A 0.79 0.08
253_Q 129_H 0.76 0.07
260_R 113_P 0.71 0.06
131_Y 154_L 0.68 0.05
343_N 84_A 0.67 0.04
107_L 119_V 0.63 0.04
257_P 122_V 0.63 0.04
348_Y 129_H 0.63 0.04
100_S 85_T 0.62 0.04
263_V 129_H 0.62 0.04
321_S 92_G 0.61 0.03
278_E 151_E 0.61 0.03
68_A 86_L 0.61 0.03
174_H 18_Y 0.60 0.03
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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