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OPENSEQ.org
4HEA_4 - 4HEA_H
UniProt: Q56220 - Q60019 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 774
Sequences: 1562
Seq/Len: 2.21
I_Prob: 0.31
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea4E:HQContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
143_L 39_L 1.41 0.31
144_T 43_Q 1.23 0.20
140_L 82_F 1.05 0.11
220_G 247_A 1.04 0.11
151_R 44_V 1.01 0.10
111_P 242_A 0.98 0.09
264_V 152_S 0.97 0.08
283_M 38_L 0.94 0.08
293_A 210_S 0.91 0.07
35_P 229_V 0.89 0.06
147_F 39_L 0.87 0.06
143_L 295_A 0.85 0.05
373_P 66_S 0.84 0.05
264_V 56_L 0.83 0.05
175_I 242_A 0.81 0.04
191_K 142_A 0.80 0.04
138_L 39_L 0.80 0.04
291_K 95_L 0.80 0.04
272_V 84_L 0.79 0.04
130_L 267_W 0.79 0.04
266_L 204_L 0.79 0.04
108_V 187_N 0.77 0.04
38_H 225_E 0.77 0.04
134_G 238_S 0.76 0.04
264_V 281_L 0.75 0.03
246_Y 156_S 0.75 0.03
133_L 72_I 0.74 0.03
103_K 285_F 0.73 0.03
143_L 40_A 0.72 0.03
190_L 208_I 0.72 0.03
216_E 258_L 0.71 0.03
52_V 237_S 0.71 0.03
337_P 286_F 0.71 0.03
195_E 96_A 0.71 0.03
28_L 319_L 0.70 0.03
203_E 291_I 0.70 0.03
348_S 57_L 0.70 0.03
109_V 139_S 0.70 0.03
52_V 56_L 0.70 0.03
198_P 128_V 0.69 0.03
234_L 281_L 0.69 0.03
401_D 223_E 0.69 0.03
103_K 37_R 0.69 0.03
109_V 102_F 0.69 0.03
390_V 168_L 0.69 0.03
264_V 73_V 0.69 0.03
109_V 196_F 0.68 0.03
64_T 254_T 0.68 0.03
369_K 146_K 0.68 0.03
259_T 76_Q 0.68 0.03
191_K 88_I 0.68 0.03
346_T 195_L 0.68 0.03
158_D 40_A 0.68 0.03
171_N 94_L 0.68 0.03
397_I 148_S 0.68 0.03
56_V 34_I 0.68 0.03
106_G 187_N 0.68 0.03
30_V 147_Y 0.68 0.03
395_A 260_P 0.68 0.03
195_E 84_L 0.68 0.03
47_L 290_F 0.68 0.03
106_G 85_A 0.67 0.02
141_G 62_D 0.67 0.02
53_L 204_L 0.67 0.02
348_S 147_Y 0.67 0.02
227_E 197_L 0.67 0.02
391_P 224_A 0.67 0.02
259_T 148_S 0.67 0.02
130_L 293_I 0.67 0.02
401_D 220_D 0.67 0.02
381_L 316_L 0.67 0.02
298_E 179_S 0.67 0.02
106_G 130_E 0.66 0.02
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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