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OPENSEQ.org
4HEA_4 - 4HEA_A
UniProt: Q56220 - Q56217 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 528
Sequences: 1023
Seq/Len: 2.03
I_Prob: 0.01
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea4E:APContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
106_G 101_L 1.13 0.01
33_Q 44_Y 1.09 0.01
386_K 50_P 1.04 0.01
126_L 16_V 0.99 0.01
387_G 17_A 0.98 0.01
201_I 30_L 0.94 0.01
281_R 83_V 0.92 0.00
51_E 25_L 0.92 0.00
109_V 78_L 0.91 0.00
28_L 41_L 0.91 0.00
372_A 32_G 0.91 0.00
393_M 117_R 0.90 0.00
172_Y 57_F 0.90 0.00
144_T 16_V 0.90 0.00
346_T 102_L 0.89 0.00
152_E 73_V 0.84 0.00
105_L 92_G 0.83 0.00
370_V 75_V 0.80 0.00
182_L 102_L 0.80 0.00
99_L 70_L 0.79 0.00
394_V 34_K 0.78 0.00
81_Y 107_F 0.77 0.00
384_A 76_A 0.77 0.00
382_P 117_R 0.77 0.00
375_F 88_L 0.77 0.00
37_T 44_Y 0.77 0.00
281_R 18_L 0.76 0.00
106_G 15_G 0.75 0.00
293_A 52_G 0.75 0.00
266_L 26_L 0.74 0.00
294_L 38_R 0.73 0.00
278_V 26_L 0.72 0.00
375_F 14_V 0.72 0.00
192_K 108_L 0.72 0.00
134_G 13_Y 0.72 0.00
131_V 78_L 0.72 0.00
73_R 85_A 0.72 0.00
108_V 42_M 0.71 0.00
91_F 79_W 0.71 0.00
261_T 97_L 0.71 0.00
260_Y 31_L 0.71 0.00
179_K 70_L 0.70 0.00
185_E 28_G 0.70 0.00
394_V 42_M 0.70 0.00
298_E 98_A 0.70 0.00
208_F 61_F 0.70 0.00
203_E 44_Y 0.70 0.00
225_P 15_G 0.70 0.00
220_G 46_S 0.69 0.00
134_G 73_V 0.69 0.00
223_V 26_L 0.69 0.00
377_N 66_M 0.69 0.00
134_G 16_V 0.69 0.00
121_N 77_F 0.69 0.00
215_Y 44_Y 0.69 0.00
130_L 32_G 0.69 0.00
103_K 61_F 0.69 0.00
386_K 14_V 0.68 0.00
397_I 35_K 0.68 0.00
295_E 15_G 0.68 0.00
342_V 26_L 0.68 0.00
228_V 17_A 0.68 0.00
178_V 27_V 0.68 0.00
276_M 111_W 0.67 0.00
301_P 20_I 0.67 0.00
389_Q 117_R 0.67 0.00
52_V 38_R 0.67 0.00
96_A 75_V 0.67 0.00
54_E 31_L 0.67 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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