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OPENSEQ.org
4HEA_5 - 4HEA_A
UniProt: Q56219 - Q56217 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 326
Sequences: 1259
Seq/Len: 4.94
I_Prob: 0.63
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea5F:AP:4EContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
88_F 102_L 1.36 0.63
113_F 58_P 1.14 0.42
88_F 12_I 1.11 0.40
29_L 12_I 1.08 0.37
149_D 77_F 1.07 0.36
94_V 10_T 1.03 0.32
140_D 73_V 1.01 0.30
51_D 110_E 1.00 0.29
138_P 46_S 0.98 0.27
119_Y 119_H 0.94 0.24
31_R 12_I 0.93 0.23
30_P 105_V 0.90 0.21
69_A 21_G 0.89 0.20
86_S 101_L 0.89 0.20
140_D 46_S 0.88 0.19
111_A 61_F 0.87 0.19
138_P 48_N 0.87 0.19
51_D 43_P 0.85 0.18
103_T 15_G 0.85 0.17
107_L 49_D 0.85 0.17
139_E 48_N 0.84 0.17
136_L 68_F 0.83 0.16
142_E 61_F 0.82 0.16
33_R 31_L 0.81 0.15
91_R 115_V 0.80 0.14
119_Y 85_A 0.80 0.14
44_M 29_A 0.80 0.14
39_A 23_A 0.79 0.14
38_M 108_L 0.79 0.14
112_N 83_V 0.79 0.14
72_Y 90_L 0.78 0.13
142_E 105_V 0.78 0.13
38_M 26_L 0.78 0.13
110_S 85_A 0.77 0.12
88_F 11_L 0.76 0.12
106_D 19_F 0.74 0.11
119_Y 28_G 0.74 0.11
65_P 61_F 0.74 0.11
127_E 94_L 0.73 0.11
27_V 7_Y 0.73 0.11
38_M 84_S 0.73 0.10
141_L 48_N 0.72 0.10
118_V 21_G 0.72 0.10
75_V 100_T 0.72 0.10
88_F 25_L 0.71 0.10
135_I 35_K 0.71 0.10
118_V 112_W 0.71 0.10
66_E 105_V 0.71 0.10
46_F 30_L 0.71 0.10
105_T 26_L 0.71 0.10
120_D 102_L 0.71 0.10
121_L 16_V 0.70 0.09
28_V 85_A 0.70 0.09
118_V 49_D 0.70 0.09
35_K 88_L 0.69 0.09
99_P 61_F 0.69 0.09
48_F 85_A 0.68 0.09
91_R 81_Y 0.68 0.09
108_W 104_F 0.68 0.09
107_L 67_L 0.68 0.08
121_L 110_E 0.68 0.08
41_Y 71_F 0.68 0.08
112_N 25_L 0.68 0.08
109_G 117_R 0.67 0.08
49_L 71_F 0.66 0.08
136_L 63_V 0.66 0.08
37_E 39_A 0.66 0.08
103_T 24_A 0.66 0.08
132_L 12_I 0.66 0.08
36_E 18_L 0.66 0.07
152_L 80_P 0.66 0.07
87_R 67_L 0.66 0.07
30_P 31_L 0.65 0.07
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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