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OPENSEQ.org
4HEA_A - 4HEA_M
UniProt: Q56217 - Q56228 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 588
Sequences: 3077
Seq/Len: 5.36
I_Prob: 0.55
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3rkoCM:BL:DN:AEContact Map
4heaMU:LT:NV:APContact Map
4he8GM:FL:IN:ABContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
117_R 233_L 1.32 0.55
99_F 341_I 1.15 0.40
62_Y 150_L 0.99 0.26
79_W 409_A 0.98 0.25
65_A 295_V 0.98 0.25
70_L 103_E 0.96 0.24
28_G 364_A 0.96 0.23
109_Y 342_G 0.96 0.23
57_F 374_F 0.94 0.22
27_V 375_P 0.92 0.20
57_F 160_L 0.92 0.20
106_G 156_S 0.92 0.20
79_W 291_S 0.91 0.20
108_L 228_D 0.91 0.19
100_T 247_P 0.90 0.19
35_K 321_Y 0.90 0.19
26_L 394_L 0.89 0.18
73_V 84_L 0.89 0.18
30_L 207_L 0.88 0.18
79_W 314_L 0.87 0.17
77_F 311_G 0.87 0.17
64_V 335_R 0.86 0.17
38_R 362_F 0.86 0.16
18_L 305_P 0.86 0.16
85_A 67_L 0.86 0.16
109_Y 285_L 0.85 0.16
105_V 399_V 0.84 0.15
59_V 66_G 0.83 0.14
109_Y 367_G 0.82 0.14
28_G 205_T 0.82 0.14
107_F 126_L 0.82 0.14
76_A 297_A 0.81 0.14
65_A 155_G 0.81 0.13
83_V 371_L 0.81 0.13
79_W 391_L 0.81 0.13
60_H 294_G 0.80 0.13
44_Y 336_T 0.80 0.13
97_L 321_Y 0.79 0.12
98_A 89_A 0.79 0.12
55_K 281_F 0.79 0.12
59_V 121_F 0.78 0.12
99_F 268_A 0.77 0.12
105_V 101_L 0.77 0.12
25_L 383_G 0.77 0.11
38_R 95_F 0.77 0.11
58_P 370_G 0.76 0.11
52_G 180_L 0.76 0.11
65_A 128_P 0.75 0.10
101_L 177_L 0.75 0.10
98_A 389_P 0.75 0.10
38_R 132_M 0.75 0.10
59_V 344_Y 0.75 0.10
35_K 132_M 0.74 0.10
88_L 115_L 0.74 0.10
107_F 320_V 0.74 0.10
111_W 233_L 0.73 0.10
97_L 210_L 0.73 0.10
75_V 306_E 0.73 0.10
70_L 132_M 0.73 0.10
78_L 308_A 0.73 0.10
22_V 316_A 0.72 0.09
101_L 65_F 0.72 0.09
106_G 222_H 0.72 0.09
99_F 176_L 0.72 0.09
78_L 354_L 0.71 0.09
85_A 166_A 0.71 0.09
61_F 325_L 0.71 0.09
109_Y 125_A 0.71 0.09
28_G 413_T 0.71 0.09
27_V 420_S 0.71 0.09
65_A 274_V 0.70 0.09
67_L 398_S 0.70 0.08
112_W 350_S 0.70 0.08
44_Y 125_A 0.70 0.08
40_K 126_L 0.70 0.08
42_M 236_V 0.69 0.08
57_F 106_L 0.69 0.08
77_F 403_A 0.69 0.08
34_K 273_W 0.69 0.08
118_W 315_L 0.69 0.08
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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