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OPENSEQ.org
4HEA_A - 4HEA_K
UniProt: Q56217 - Q56226 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 214
Sequences: 2806
Seq/Len: 13.36
I_Prob: 0.86
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3rkoAE:GKContact Map
4heaAP:KSContact Map
4he8AB:EKContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
77_F 62_A 1.49 0.86
60_H 82_R 1.22 0.67
69_I 65_A 1.19 0.64
28_G 14_G 1.09 0.54
76_A 79_F 1.08 0.54
101_L 43_V 1.08 0.53
89_G 43_V 1.08 0.53
84_S 31_I 1.08 0.53
65_A 49_Y 1.08 0.53
79_W 34_M 1.08 0.53
76_A 68_V 1.06 0.51
48_N 36_N 1.06 0.51
27_V 35_L 1.05 0.50
98_A 55_V 1.05 0.49
115_V 64_A 1.03 0.48
73_V 61_I 1.02 0.46
50_P 92_E 1.01 0.45
52_G 38_A 1.00 0.44
97_L 53_G 0.99 0.43
112_W 56_A 0.99 0.43
66_M 19_L 0.98 0.41
73_V 62_A 0.97 0.41
89_G 56_A 0.97 0.41
102_L 16_Y 0.96 0.40
80_P 33_L 0.92 0.35
37_G 77_A 0.91 0.34
108_L 79_F 0.91 0.34
70_L 93_L 0.91 0.34
104_F 44_G 0.90 0.33
102_L 48_A 0.90 0.33
117_R 16_Y 0.89 0.33
29_A 13_L 0.89 0.32
112_W 14_G 0.89 0.32
60_H 68_V 0.89 0.32
95_G 14_G 0.89 0.32
79_W 27_V 0.89 0.32
54_V 28_F 0.88 0.31
103_L 74_L 0.88 0.31
113_K 87_V 0.87 0.30
100_T 49_Y 0.87 0.30
107_F 23_T 0.87 0.30
99_F 53_G 0.87 0.30
99_F 25_I 0.86 0.29
109_Y 65_A 0.86 0.29
25_L 50_G 0.86 0.29
34_K 40_L 0.85 0.28
59_V 15_V 0.85 0.28
43_P 24_A 0.85 0.28
97_L 46_A 0.84 0.28
64_V 18_V 0.84 0.28
37_G 23_T 0.84 0.27
55_K 26_L 0.84 0.27
109_Y 17_G 0.83 0.26
99_F 55_V 0.83 0.26
72_D 71_G 0.83 0.26
92_G 56_A 0.82 0.25
28_G 42_L 0.82 0.25
118_W 65_A 0.82 0.25
117_R 27_V 0.82 0.25
44_Y 17_G 0.81 0.24
49_D 38_A 0.81 0.24
21_G 26_L 0.81 0.24
115_V 17_G 0.81 0.24
76_A 94_R 0.81 0.24
81_Y 64_A 0.81 0.24
19_F 55_V 0.80 0.23
19_F 53_G 0.80 0.23
38_R 52_D 0.80 0.23
98_A 16_Y 0.80 0.23
101_L 54_Q 0.79 0.23
119_H 70_V 0.79 0.22
83_V 47_R 0.78 0.22
97_L 43_V 0.78 0.22
81_Y 74_L 0.78 0.21
36_P 64_A 0.78 0.21
52_G 14_G 0.78 0.21
19_F 50_G 0.78 0.21
49_D 81_H 0.77 0.21
97_L 16_Y 0.77 0.20
97_L 10_L 0.77 0.20
60_H 26_L 0.76 0.20
105_V 9_L 0.76 0.20
83_V 54_Q 0.76 0.20
97_L 48_A 0.76 0.19
79_W 10_L 0.75 0.19
52_G 18_V 0.75 0.19
108_L 20_T 0.75 0.19
108_L 86_A 0.75 0.19
38_R 12_A 0.75 0.19
66_M 88_D 0.75 0.19
67_L 26_L 0.75 0.19
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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