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HIS4 - HISX
UniProt: P10371 - P06988
Length: 679
Sequences: 721
Seq/Len: 1.08
I_Prob: 0.00

HIS4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Paralog alert: 0.96 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: HIS4 HIS6
HISX - Histidinol dehydrogenase
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HISX
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
184_V 271_L 1.11 0.00
67_T 287_R 1.09 0.00
165_L 141_T 0.98 0.00
211_V 193_L 0.98 0.00
179_L 106_P 0.94 0.00
82_V 381_L 0.92 0.00
233_F 161_S 0.90 0.00
124_L 141_T 0.90 0.00
154_E 200_V 0.89 0.00
40_A 309_V 0.88 0.00
178_T 301_A 0.87 0.00
237_E 309_V 0.87 0.00
230_E 200_V 0.87 0.00
96_V 34_R 0.86 0.00
180_A 354_S 0.86 0.00
23_K 423_V 0.85 0.00
32_L 213_F 0.81 0.00
128_L 319_I 0.80 0.00
215_R 213_F 0.80 0.00
86_E 41_D 0.78 0.00
200_Q 173_A 0.78 0.00
20_D 350_L 0.77 0.00
13_V 239_V 0.77 0.00
87_D 94_N 0.77 0.00
168_V 265_D 0.75 0.00
76_V 422_A 0.74 0.00
200_Q 55_S 0.74 0.00
237_E 100_T 0.74 0.00
65_I 310_T 0.73 0.00
26_D 422_A 0.73 0.00
114_G 355_P 0.73 0.00
25_R 376_A 0.73 0.00
84_S 283_E 0.73 0.00
78_V 157_V 0.73 0.00
187_Y 141_T 0.72 0.00
173_I 20_L 0.72 0.00
30_D 312_D 0.71 0.00
146_Q 385_D 0.71 0.00
38_Y 166_A 0.71 0.00
231_G 38_D 0.71 0.00
110_D 89_A 0.70 0.00
41_Q 44_K 0.70 0.00
142_V 385_D 0.70 0.00
128_L 368_V 0.70 0.00
200_Q 215_T 0.70 0.00
187_Y 151_I 0.69 0.00
179_L 36_V 0.69 0.00
213_A 60_K 0.69 0.00
114_G 35_T 0.69 0.00
215_R 324_G 0.69 0.00
103_S 104_L 0.69 0.00
179_L 258_S 0.69 0.00
101_V 124_V 0.69 0.00
112_V 306_R 0.69 0.00
83_R 139_F 0.69 0.00
106_V 331_Q 0.69 0.00
113_K 199_S 0.69 0.00
175_R 125_A 0.69 0.00
3_I 61_T 0.69 0.00
187_Y 117_C 0.68 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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