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OPENSEQ.org

1EP3_A - 1EP3_B
PDB: 1EP3 Query Sequences:

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 572
Sequences: 552
Seq/Len: 0.99
I_Prob: 0.87
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
70_M 224_A 2.12 0.87
74_I 232_A 1.54 0.49
49_A 231_Y 1.41 0.37
271_T 49_L 1.37 0.33
274_F 224_A 1.30 0.28
105_V 234_V 1.25 0.23
228_V 22_M 1.24 0.23
102_I 191_D 1.18 0.19
225_I 91_V 1.15 0.17
299_L 250_D 1.07 0.12
60_T 244_A 1.04 0.11
230_L 111_K 1.04 0.11
104_N 229_A 1.00 0.10
77_Q 234_V 0.99 0.09
104_N 52_R 0.99 0.09
33_Y 229_A 0.97 0.08
44_S 194_Y 0.97 0.08
116_V 250_D 0.96 0.08
104_N 231_Y 0.95 0.08
63_V 232_A 0.95 0.07
274_F 227_I 0.94 0.07
64_A 222_R 0.94 0.07
158_A 20_F 0.92 0.07
269_V 80_Y 0.91 0.07
60_T 234_V 0.90 0.06
66_T 224_A 0.90 0.06
159_C 127_L 0.90 0.06
183_K 130_Q 0.89 0.06
102_I 35_P 0.89 0.06
230_L 18_N 0.89 0.06
111_A 68_I 0.88 0.06
133_I 216_Y 0.88 0.05
56_F 169_D 0.87 0.05
103_A 150_K 0.86 0.05
51_T 54_I 0.85 0.05
259_M 91_V 0.85 0.05
15_D 89_A 0.85 0.05
39_L 202_L 0.84 0.05
175_V 68_I 0.84 0.05
11_L 82_L 0.84 0.05
274_F 231_Y 0.84 0.05
167_L 151_I 0.84 0.04
33_Y 94_M 0.83 0.04
68_S 46_G 0.83 0.04
34_A 160_K 0.83 0.04
175_V 39_L 0.83 0.04
76_L 117_G 0.82 0.04
61_P 234_V 0.82 0.04
173_P 196_C 0.81 0.04
291_M 82_L 0.81 0.04
288_P 219_M 0.81 0.04
61_P 160_K 0.81 0.04
50_T 40_H 0.81 0.04
138_V 218_S 0.80 0.04
120_I 181_M 0.80 0.04
77_Q 119_I 0.80 0.04
144_A 124_L 0.80 0.04
285_D 41_L 0.80 0.04
194_T 231_Y 0.80 0.04
62_R 50_L 0.80 0.04
292_D 22_M 0.80 0.04
296_I 13_R 0.80 0.04
274_F 229_A 0.79 0.04
24_S 41_L 0.78 0.04
156_V 221_S 0.78 0.04
193_L 119_I 0.78 0.03
276_D 91_V 0.78 0.03
77_Q 246_K 0.78 0.03
62_R 52_R 0.77 0.03
269_V 64_K 0.77 0.03
212_I 18_N 0.77 0.03
300_E 236_H 0.77 0.03
11_L 159_L 0.77 0.03
172_S 124_L 0.76 0.03
268_A 250_D 0.76 0.03
204_F 219_M 0.76 0.03
80_G 220_E 0.76 0.03
253_A 229_A 0.75 0.03
112_D 175_T 0.75 0.03
39_L 234_V 0.75 0.03
109_E 124_L 0.75 0.03
182_A 220_E 0.75 0.03
38_D 194_Y 0.75 0.03
225_I 169_D 0.75 0.03
212_I 222_R 0.75 0.03
54_P 172_S 0.74 0.03
286_K 224_A 0.74 0.03
20_I 115_I 0.74 0.03
11_L 24_L 0.74 0.03
168_Y 54_I 0.73 0.03
41_K 214_R 0.73 0.03
269_V 89_A 0.73 0.03
269_V 239_E 0.73 0.03
98_E 232_A 0.73 0.03
28_G 229_A 0.73 0.03
33_Y 227_I 0.73 0.03
76_L 177_G 0.73 0.03
81_L 142_L 0.72 0.03
188_A 138_M 0.72 0.03
203_R 122_P 0.72 0.03
77_Q 57_S 0.72 0.03
88_K 141_L 0.72 0.03
60_T 221_S 0.72 0.03
126_V 169_D 0.72 0.03
112_D 183_M 0.72 0.03
114_V 12_Q 0.72 0.03
157_K 35_P 0.71 0.02
46_M 240_D 0.71 0.02
168_Y 126_E 0.71 0.02
244_I 195_T 0.71 0.02
149_P 166_I 0.71 0.02
157_K 191_D 0.71 0.02
70_M 232_A 0.71 0.02
137_N 224_A 0.71 0.02
104_N 198_A 0.71 0.02
212_I 139_T 0.71 0.02
260_Y 239_E 0.71 0.02
195_M 249_E 0.71 0.02
168_Y 231_Y 0.71 0.02
63_V 104_A 0.71 0.02
81_L 41_L 0.71 0.02
62_R 224_A 0.71 0.02
124_A 68_I 0.70 0.02
84_I 79_T 0.70 0.02
103_A 232_A 0.70 0.02
74_I 7_M 0.70 0.02
78_N 117_G 0.70 0.02
108_S 156_F 0.70 0.02
107_G 168_T 0.70 0.02
243_P 196_C 0.70 0.02
212_I 92_D 0.70 0.02
179_V 67_T 0.70 0.02
92_L 200_A 0.70 0.02
169_V 71_R 0.70 0.02
76_L 143_G 0.70 0.02
21_I 240_D 0.69 0.02
295_R 90_K 0.69 0.02
169_V 123_P 0.69 0.02
208_T 154_N 0.69 0.02
15_D 45_N 0.69 0.02
76_L 174_G 0.69 0.02
275_A 48_M 0.69 0.02
36_Y 94_M 0.69 0.02
133_I 224_A 0.69 0.02
290_L 194_Y 0.69 0.02
14_L 124_L 0.69 0.02
20_I 86_E 0.69 0.02
27_F 229_A 0.69 0.02
126_V 216_Y 0.69 0.02
51_T 51_R 0.68 0.02
291_M 92_D 0.68 0.02
256_V 215_L 0.68 0.02
117_C 51_R 0.68 0.02
258_E 193_L 0.68 0.02
294_Y 35_P 0.68 0.02
10_K 191_D 0.68 0.02
269_V 214_R 0.68 0.02
21_I 150_K 0.68 0.02
105_V 187_D 0.68 0.02
74_I 216_Y 0.68 0.02
79_P 144_F 0.67 0.02
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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